Home  >  Products  >  Doxorubicin (Adriamycin, 14-Hydroxydaunomycin, Adriacin, Adriblastin, Caelyx, Dox, Doxil, Farmiblastina, FI 106, K 1039, KW 125, NSC 123127)
Doxorubicin (Adriamycin, 14-Hydroxydaunomycin, Adriacin, Adriblastin, Caelyx, Dox, Doxil, Farmiblastina, FI 106, K 1039, KW 125, NSC 123127)

Doxorubicin (Adriamycin, 14-Hydroxydaunomycin, Adriacin, Adriblastin, Caelyx, Dox, Doxil, Farmiblastina, FI 106, K 1039, KW 125, NSC 123127)

Cat no: D9099-43

Supplier: United States Biological
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Doxorubicin is the most extensively studied of a family of highly fluorescent anthracycline antibiotics produced by several Streptomyces species, first reported in 1967 and later approved for human therapeutic use as an antitumor agent for the treatment of a wide range of cancers. Doxorubicin has also been reported to exhibit anti-HIV and antibacterial activity. The mode of action of doxorubicin is thought to be due to intercalation of DNA and inhibition of nucleic acid synthesis. Apperance: As Reported Solubility: As Reported Storage and Stability: Lyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Soluble in ethanol, methanol, DMSO and DMF. Poor water solubility. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Light Sensitive.
Catalogue number: D9099-43
Size: 25mg
Form: As Reported
Purity: ~99% (HPLC)
References: US Biological application reference: Abouzeid, A.H., et al., (2013) J Drug Target., doi:10.3109/1061186X.2013.840639. 1. Adriamycin (14-hydroxydaunomycin), a novel antitumor antibiotic. Arcamone F. et al., Tet. Letters 1969, 13, 1007. 2. Interference by doxorubicin with DNA unwinding in MCF-7 breast tumor cells. Fornari F.L. et al., Mol. Pharmacology 1994, 45, 649. 3. Effect of Adriamycin on DNA, RNA, and protein synthesis in cell-free systems and intact cells. Momarier R. et al., Cancer Research 1976, 36, 2891.

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