Home  >  Products  >  DPM1 (Dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit, RP23-391M18.1, AI118379, AI194292, OTTMUSP00000017164, dolichol monophosphate mannose synthase, dolichyl-phosphate mannosyltransferase polypeptide 1)
DPM1 (Dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit, RP23-391M18.1, AI118379, AI194292, OTTMUSP00000017164, dolichol monophosphate mannose synthase, dolichyl-phosphate mannosyltransferase polypeptide 1)

DPM1 (Dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit, RP23-391M18.1, AI118379, AI194292, OTTMUSP00000017164, dolichol monophosphate mannose synthase, dolichyl-phosphate mannosyltransferase polypeptide 1)

Cat no: D9150-79

Supplier: United States Biological
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Dolichol-phosphate mannose (DPM1) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER). Defective surface expression of GPI-anchored proteins occurs when there is a lack of DPM1. DPM1 is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase. Human DPM1 lacks a carboxy-terminal transmembrane domain and signal sequence and is regulated by DPM2. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:64,000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: D9150-79
Reactivities: Rat
Hosts: Goat
Applications: Western Blot
Size: 100ug
Form: Supplied as a liquid in Tris saline, 0.02% sodium azide, pH7.3, 0.5% BSA.
P type: Pab
Isotype: IgG
Purity: Purified by affinity chromatography.
References: 1. Ashida H, Maeda Y, Kinoshita T. DPM1, the catalytic subunit of dolichol-phosphate mannose synthase, is tethered to and stabilized on the endoplasmic reticulum membrane by DPM3. J Biol Chem. 2006 Jan 13;281(2):896-904. PMID: 16280320.
Additional info: Recognizes rat DPM1. Sequence Homology: mouse.

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