Home  >  Products  >  DPM2 (Dolichol-phosphate (beta-D) Mannosyltransferase 2, RP23-255P20.5, AW557993, R75484, OTTMUSP00000012854)
DPM2 (Dolichol-phosphate (beta-D) Mannosyltransferase 2, RP23-255P20.5, AW557993, R75484, OTTMUSP00000012854)

DPM2 (Dolichol-phosphate (beta-D) Mannosyltransferase 2, RP23-255P20.5, AW557993, R75484, OTTMUSP00000012854)

Cat no: D9150-80

Supplier: United States Biological
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Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER). Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins. Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase. The protein encoded by this gene is a hydrophobic protein that contains 2 predicted transmembrane domains and a putative ER localization signal near the C terminus. This protein associates with DPM1 in vivo and is required for the ER localization and stable expression of DPM1 and also enhances the binding of dolichol-phosphate to DPM1. Applications: Suitable for use in ELISA. Other applications not tested. Recommended Dilution: ELISA: 1:16000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: D9150-80
Reactivities: Human
Hosts: Goat
Applications: ELISA
Size: 100ug
Form: Supplied as a liquid in Tris, pH 7.2, 0.5% BSA, 0.02% sodium azide.
P type: Pab
Purity: Purified by affinity chromatography.
References: 1. Watanabe R, Murakami Y, Marmor MD, Inoue N, Maeda Y, Hino J, Kangawa K, Julius M, Kinoshita T. Initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-P and is regulated by DPM2. EMBO J. 2000 Aug 15;19(16):4402-11. PMID: 10944123
Additional info: Recognizes mouse DPM2.

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