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DR3, CT, Blocking Peptide (Wsl-1, Apo-3, TRAMP, LARD1-5, Death Receptor3)

Cat no: D9300P

DR3, CT, Blocking Peptide (Wsl-1, Apo-3, TRAMP, LARD1-5, Death Receptor3)

Peptide corresponding to amino acids 398 to 417 of human DR3.\nApoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNFR1 and Fas. A novel cell death receptor was recently identified by several groups independently and designated DR3, Wsl-1, Apo-3, TRAMP and LARD1-5. The ligand for this novel cell death receptor has not yet been defined. DR3 is highly expressed in the tissues enriched in lymphocytes including PBL, thymus and spleen. Like TNFR1, DR3 induces apoptosis and NF-kB activation.

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SPECIFICATIONS

Catalog Number

D9300P

Size

50ug

Form

Supplied as a lyophilized powder.

Purity

Purified 60-70%

References

1. Chinnaiyan AM; O'Rourke K; Yu GL; Lyons RH; Garg M; Duan DR; Xing L; Gentz R; Ni J; Dixit VM. Science, 1996;274:990-2.\n\n2. Kitson J; Raven T; Jiang YP; Goeddel DV; Giles KM; Pun KT; Grinham CJ; Brown R; Farrow SN. Nature, 1996;384:372-5.\n\n3. Marsters SA; Sheridan JP; Donahue CJ; Pitti RM; Gray CL; Goddard AD; Bauer KD; Ashkenazi A. Curr Biol, 1996;6:1669-76.\n\n4. Bodmer JL; Burns K; Schneider P; Hofmann K; Steiner V; Thome M; Bornand T; Hahne M; Schroter M; Becker K; et al. Immunity, 1997;6:79-88.\n\n5. Screaton GR; Xu XN; Olsen AL; Cowper AE; Tan R; McMichael AJ; Bell JI. Proc. Nat. Acad. Sci. USA. 1997;94:4615-9. \n

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