DR5, ID (Tumor Necrosis Factor Receptor Superfamily Member 10B, Death Receptor 5, TNF-related Apoptosis-inducing Ligand Receptor 2, TRAIL Receptor 2, TRAIL-R2, CD262, TNFRSF10B, KILLER, TRAILR2, TRICK2, ZTNFR9, UNQ160/PRO186)

Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family. DR4 was recently identified as the receptor for TRAIL. A novel death domain containing receptor for TRAIL was more recently identified and designated DR5, Apo2, TRAIL-R2, TRICK2, or KILLER by several groups independently. Like DR4, DR5 transcript is widely expressed in normal tissues and in many types of tumor cells. DR5 binds to TRAIL and mediates TRAIL induced cell death. Overexpression of DR5 induces apoptosis and activates NF-kB.\n\nApplications:\nSuitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested.\n\nRecommended Dilution:\nELISA: 1:5000-1:20,000\nWestern Blot: 1:500-1:1000\nImmunohistochemistry: 1:50-1:200\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

D9300-54D

Size

50ug

Applications

ELISA, IHC, WB

Hosts

Rabbit

Reactivities

Hum

Form

Supplied as a liquid in PBS, pH 7.4, 0.05% sodium azide.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

References

1. Pan, G. et al. Science 277, 815 (1997). 2. Sheridan, JP. et al. Science 277, 818 (1997). 3. Walczak, H. et al. EMBO J 16, 5386 (1997). 4. MacFarlane, M. et al. J. Biol. Chem.272, 25417 (1997). 5. Screaton, GR. et al. Curr. Biol. 7, 693 (1997). 6. Wu, GS. et al. Nat. Genet 17, 141 (1997). 7. Chaudhary PM. et al. Immunity 7, 821 (1997).

Additional Info

Recognizes human DR5.