Human sTRAIL Receptor-2, also known as DR5 (Death Receptor-5), is a member of the TNF receptor family. The recombinant human sTRAIL Receptor-2 is a 14.9kD protein containing 133aa residues comprising the extracellular domain of TRAIL Receptor-2.
Source:
Recombinant corresponding to human DR5 expressed in E. coli.
Molecular Weight:
~14.9kD
Endotoxin Level:
<0.1ng/ug
Biological Activity:
Determined by its inhibitory effect of IL-8 production in human PBMC by human sTRAIL/Apo2L. 50% inhibition (100ng/ml of sTRAIL/Apo2L) was reached using a concentration of 1000ng/ml of sTRAIL Receptor-2.
Storage and Stability:
Lyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with sterile dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Reconstituted product is stable for 6 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.