DR5, soluble Recombinant, Human (Apo2, Trail-R2, TRAIL Receptor2, Trick2, Killer, Death Receptor5, CD262, KILLER, KILLER/DR5, TNFRSF10B, TRANCE-R, TRICKB, Tumor Necrosis Factor Receptor Superfamily, Member 10b, ZTNFR9)

Supplier:

United States Biological

Cat no: D9300-51

DR5, soluble Recombinant, Human (Apo2, Trail-R2, TRAIL Receptor2, Trick2, Killer, Death Receptor5, CD262, KILLER, KILLER/DR5, TNFRSF10B, TRANCE-R, TRICKB, Tumor Necrosis Factor Receptor Superfamily, Member 10b, ZTNFR9)

Human sTRAIL Receptor-2, also known as DR5 (Death Receptor-5), is a member of the TNF receptor family. Human sTRAIL Receptor-2 is a 14.9kD protein containing 133 amino acid residues comprising the extracellular domain of TRAIL Receptor-2. Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family. DR4 was recently identified as the receptor for TRAIL. A novel death domain containing receptor for TRAIL was more recently identified and designated DR5, Apo2, TRAIL-R2, TRICK2, or KILLER by several groups independently (1-7). Like DR4, DR5 transcript is widely expressed in normal tissues and in many types of tumor cells. DR5 binds to TRAIL and mediates TRAIL induced cell death. Overexpression of DR5 induces apoptosis and activates NF-kB.\n\nBiological Activity: \nDetermined by its inhibitory effect of IL-8 produced in human PBMC (peripheral blood mononuclear cells) by human sTRAIL/Apo2L. 50% inhibition (100ng/ml of sTRAIL/Apo2L) was reached using a concentration of 1000ng/ml of sTRAIL Receptor-2. \n\nAA Sequence: \nMESALITQQD LAPQQRVAPQ QKRSSPSEGL CPPGHHISED GRDCISCKYG QDYSTHWNDL LFCLRCTRCD SGEVELSPCT TTRNTVCQCE EGTFREEDSP EMCRKCRTGC PRGMVKVGDC TPWSDIECVH KES\n\nStorage and Stability:\nLyophilized powder may be stored at -20 degrees C. Reconstitute to nominal volume by adding sterile ddH2O, carrier protein. Aliquot and store at -20 degrees C. Reconstituted product is stable for 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.\n\nCountry of Origin: USA

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SPECIFICATIONS

Catalog Number

D9300-51

Size

10ug

Form

Supplied as a lyophilized powder with no additives. Reconsitutie with ddH2O, carrier protein to 0.1-1mg/ml. This solution can then be diluted into other aqueous buffers.

Purity

(same/more than) 98% by SDS-PAGE and HPLC analyses. Endotoxin: (same/less than) 0.1ng/ug (1EU/ug)

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SUPPLIER INFO

United States Biological

Address:

4 Technology Way, Salem, MA 01970, US

Phone:

+1 800 520 3011

Website:

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