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DRAK1, NT, Blocking Peptide (DAP Kinase-related Apoptosis-inducing Protein Kinase 1)

Cat no: D9334P

DRAK1, NT, Blocking Peptide (DAP Kinase-related Apoptosis-inducing Protein Kinase 1)

Peptide corresponding to amino acids 5 to 19 of human DRAK1 (1). \nApoptosis is mediated by death domain containing adapter molecules and a caspase family of proteases. Certain serine/threonine protein kinases, such as ASK-1 and RIP, are mediators of apoptosis. Two novel serine/threonine kinases that induce apoptosis were recently identified and designated DRAK1 and DRAK2 for DAP kinase-related apoptosis-inducing protein kinases (1). DRAKs contain an N-terminal kinase domain and a C-terminal regulation domain. Overexpression of DRAK1 induces apoptosis. DRAKs have high sequence homology to DAP and ZIP kinases, and they represent a novel family of serine/threonine kinases, which mediates apoptosis through their catalytic activities. DRAK1 is located in nucleus and the messenger RNA was ubiquitously expressed in human tissues (1).

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SPECIFICATIONS

Catalog Number

D9334P

Size

50ug

Form

Supplied as a lyophilized powder.

Purity

Purified 60-70%

References

1. Sanjo H, Kawai T, Akira S. DRAKs, novel serine/threonine kinases related to death-associated protein kinase that trigger apoptosis. J Biol Chem 1998;273:29066-71

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