DRAK1, NT (DAP Kinase-related Apoptosis-inducing Protein Kinase 1)

Apoptosis is mediated by death domain containing adapter molecules and a caspase family of proteases. Certain serine/threonine protein kinases, such as ASK-1 and RIP, are mediators of apoptosis. Two novel serine/threonine kinases that induce apoptosis were recently identified and designated DRAK1 and DRAK2 for DAP kinase-related apoptosis-inducing protein kinases (1). DRAKs contain an N-terminal kinase domain and a C-terminal regulation domain. Overexpression of DRAK1 induces apoptosis. DRAKs have high sequence homology to DAP and ZIP kinases, and they represent a novel family of serine/threonine kinases, which mediates apoptosis through their catalytic activities. DRAK1 is located in nucleus and the messenger RNA was ubiquitously expressed in human tissues (1). \n\n This polyclonal antibody can be used for detection of DRAK1 by Western blot at 1:500 to 1:1000 dilution. A431 or MOLT4 whole cell lysate can be used as positive control and an approximately 50kD band can be detected. It is human, mouse, and rat reactive, and has no cross responses to DRAK2, DAP or ZIP kinases.

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SPECIFICATIONS

Catalog Number

D9334

Size

100ug

Applications

WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

Supplied as a liquid in PBS, 0.02% sodium azide.

P Type

Pab

Purity

Immunoaffinity purified IgG

Isotype

IgG

References

1. Sanjo H, Kawai T, Akira S. DRAKs, novel serine/threonine kinases related to death-associated protein kinase that trigger apoptosis. J Biol Chem 1998;273:29066-71.

Additional Info

Recognizes human, mouse and rat DRAK1 (NT)