Two novel serine/threonine kinases that induce apoptosis were recently identified and designated DRAK1 and DRAK2 (for DAP kinase-related apoptosis-inducing protein kinases). DRAKs contain an N-terminal kinase domain and a C-terminal regulation domain. Overexpression of DRAK2 induces apoptosis. DRAK2 is located in nucleus and the messenger RNA was ubiquitously expressed in human tissue. STK17B, a DAPK type protein kinase, functions in apoptotic signaling. In vitro assays have shown that protein is autophosphorylated. Messanger RNAs of various in sizes have been reported, likely due to differences of 3' untranslated region.
Applications:
Suitable for use in mmunohistochemistry. Other applications not tested.
Recommended Dilution:
Immunohistochemistry (Formalin fixed paraffin embedded): 1:50
Optimal dilutions to be determined by the researcher.
Storage and Stability:
May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
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