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DRAM1 (DNA Damage-regulated Autophagy Modulator Protein 1, Damage-regulated Autophagy Modulator, DRAM)

DRAM1 (DNA Damage-regulated Autophagy Modulator Protein 1, Damage-regulated Autophagy Modulator, DRAM)

Cat no: D9370-02B

Supplier: United States Biological
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DRAM is an important lysosomal membrane protein of the p53 tumor suppressor pathway. It is required for the induction of macroautophagy and as an effector of p53-mediated death. DRAM expression is induced due to cellular stress via endogenous p53 leading to bulk degradation of cytoplasmic components. It is necessary but not sufficient for apoptotic cell death from p53, while over expression of DRAM alone causes minimal cell death. Quantitative PCR revealed that DRAM was significantly down regulated in tumor cell lines by methylation-dependent transcriptional silencing, particularly in cancers lacking other mechanisms of p53 inactivation. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 0.5-2ug/ml Immunohistochemistry (formalin fixed paraffin embedded): 5ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: D9370-02B
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by Protein G affinity Chromatography.
References: 1. Crighton, D. et al. Cell. 126:121-134 (2006).
Additional info: Recognizes human DRAM. Species Crossreactivity: chimpanzee, mouse, rat. Species sequence homology: monkey, canine, opossum.

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