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DRAM2 (DNA Damage-regulated Autophagy Modulator Protein 2, Transmembrane Protein 77, TMEM77, PSEC0031, UNQ154/PRO180)

Cat no: 029456

DRAM2 (DNA Damage-regulated Autophagy Modulator Protein 2, Transmembrane Protein 77, TMEM77, PSEC0031, UNQ154/PRO180)

Damage-Regulated Autophagy Modulator is a lysosomal protein that acts as an effector molecule that is critical for autophagy and p53-mediated apoptosis. In humans, there are 5 known proteins that show significant homology to DRAM. The closest of these proteins is DRAM2, which displays 67% conservation when compared to DRAM. However, unlike DRAM, DRAM2 is not induced by p53 or p73. Additionally, it does not modulate autophagy in contrast with DRAM. DRAM2 is known to be co-localized with DRAM in lysosomes, and co-expression with DRAM is shown to significantly increase cell death.\n\nApplications:\nSuitable for use in Western Blot. Other applications not tested.\n\nRecommended Dilution:\nWestern Blot:1ug/ml\nOptimal dilutions to be determined by the researcher.\n\nPositive Control:\nHuman placenta tissue lysate\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

029456

Size

100ug

Applications

WB

Hosts

Mouse

Reactivities

Hum

Form

Supplied as a liquid in 0.1M Tris-glycine, pH 7.4, 150mM sodium chloride, 0.05% sodium azide.

P Type

Mab

Purity

Purified by Protein G affinity chromatography.

Isotype

IgG2a,k

References

1. Park, S.M., et al. (2009). Biochem Biophys Res Commun. 390(4):1340-1344. 2. O'Prey, J., et al. (2009). Cell Cycle. 8(14): 2260-2265.

Additional Info

Recognizes human DRAM2.

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SUPPLIER INFO

Applications

ELISA

Reactivities

Hum

More info

Applications

IF

Hosts

Mouse

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Applications

ELISA, WB

Hosts

Mouse

Reactivities

Hum

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Applications

ELISA, FC, WB

Hosts

Mouse

Reactivities

Hum

More info

Applications

ELISA, FC, IHC, WB

Hosts

Mouse

More info

Applications

IHC, WB

Hosts

Rabbit

Reactivities

Hum

More info

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Hum

More info

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