DRD5 pAb

D5DR (dopamine receptor D5, DR1B, DRD1L2) is a G protein-coupled receptor of the D1-like family that stimulates adenylyl cyclase and has a 10-fold higher affinity for dopamine than the D1 subtype. D5DR is present in neurons in the limbic regions of the brain. D5DR mRNA is most abundant in discrete cortical areas (layers II, IV and VI), the dentate gyrus and hippocampal subfields with low levels in the striatum. There are five major types of dopamine receptors. All are G protein-coupled metabotropic receptors, and can be excitatory or inhibitory to the post-synaptic neuron. D1 (D1A, D1C, D1D) and D5 (D1B) receptors belong to the D1-like receptor family. The D2, D3 and D4 receptors belong to the D2-like receptor family. Activation of the D1-like family receptors couples to increases in cAMP and is typically excitatory, while D2-like activation reduces cAMP and is typically inhibitory. Significant age-related decline in dopamine receptor mRNAs occurs in the hippocampus and entorhinal cortex.

Prices direct from Bioworld Technology, Inc.

Quick response times

Exclusive Biosave savings/discounts

SPECIFICATIONS

Catalog Number

BS6588

Size

100ug/100ul

Applications

IHC, WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

liquid

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Antigen

Recombinant full length Human DRD5.

Species

DRD5 pAb detects endogenous levels of DRD5 protein.

Dilutions

WB: 1:500~1:2000\nIHC: 1:50~1:200

Swiss Prot

P21918

Storage Temp

Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.

Concentration

1ug/ul

Storage Buffer

1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Additional Info

For research use only, not for use in diagnostic procedure.

Molecular Weight

~ 53 kDa

Alternative Names

D(1B) dopamine receptor; D(5) dopamine receptor; D1 beta dopamine receptor; D1B dopamine receptor; D1beta dopamine receptor; D5 dopamine receptor; DBDR; Dopamine receptor D1B; DRD 1B; DRD 5; DRD1B; DRD1L2; DRD5; MGC10601;