Home  >  Products  >  Drebrin (D0S117E, Drebrin 1, DBN 1, DBN1, Developmentally Regulated Brain Protein, DKFZp434D064, Drebrin E)
Drebrin (D0S117E, Drebrin 1, DBN 1, DBN1, Developmentally Regulated Brain Protein, DKFZp434D064, Drebrin E)

Drebrin (D0S117E, Drebrin 1, DBN 1, DBN1, Developmentally Regulated Brain Protein, DKFZp434D064, Drebrin E)

Cat no: D9452-01A

Supplier: United States Biological
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Drebrins are actin-binding proteins, that are developmentally regulated in the process of neuronal growth. Three isoforms, E1 and E2 (embryonic) and A (adult) are generated by alternative RNA splicing from a single debrin gene in the chicken brain. The expression pattern of each isoform is regulated spatially and temporally in the developing brain. It has been suggested that debrin is one of the intracellular regulators of the neuronal morphogenesis (4). Debrin has also been detected in other kinds of non-neuronal human and bovine tissue but its exact role is unknown. Cellular Localization: Cytoplasmic Positive Control: Mouse Brain Tissue Extract. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: D9452-01A
Reactivities: Human, Mouse, Rat, Chicken/Bird, Guinea Pig
Hosts: Mouse
Applications: Immunohistochemistry, Western Blot
Size: 50ug
Form: PBS with 10mg/ml Sucrose [pH 7.2]
P type: Mab
Isotype: IgG
Purity: Purified by Protein A affinity chromatography.
Alternative names: D0S117E, Drebrin 1, DBN 1, DBN1, Developmentally Regulated Brain Protein, DKFZp434D064, Drebrin E
References: 1. Shirao, T. and Obata, K. (1986) Brain Res. 394, 233-244. 2. Imamura, K., et al. (1992) Neurosci Res. 13, 33-41. 3. Kojima, N., et al. (1988) Brain Res. 464, 207-215. 4. Shirao, T. (1995) J Biochem. 117, 231-236. 5. Peitsch, W.K., et al. (1999) Eur J Cell Biol. 78, 767-778.
Additional info: This antibody detects Drebrin A and E in samples from human, mouse, rat, guinea pig, and cat origins and Drebrin E only in chicken samples. Species Crossreactivity: Crossreacts with Human, Mouse, Rat, Cat, Chicken and Guinea pig.

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