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Ds(+)-threo-Isocitric acid trisodium salt ((1R,2S)-1-Hydroxy-1,2,3-propanetricarboxylic acid, (2R,3S)-Isocitric acid . trisodium salt)

Ds(+)-threo-Isocitric acid trisodium salt ((1R,2S)-1-Hydroxy-1,2,3-propanetricarboxylic acid, (2R,3S)-Isocitric acid . trisodium salt)

Cat no: 044766

Supplier: United States Biological
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Anticoagulant that retains platelets functionality. Buffers Ca2+ activity in physiological range (~1mM). Bypasses the metabolic blockade, may permit heme biosynthesis but does not suffice to reverse the iron-restriction response. Stabilizes the iron-sulfur cluster and is predicted to restore aconitase to its 'high iron' conformation and thereby dissociates the PKC-associated signaling complexes whose hyperactivation impairs Epo responsiveness. Binds IDH (isocitrate dehydrogenase), an excellent candidate for participating, along with aconitase and PKC, in an iron restriction signalosome. Contributes to heme biosynthesis which may account for its greater potency in restoring erythroid differentiation. Storage and Stability: Short-term Storage: +4 degrees C Long-term Storage: -20 degrees C Stable for at least 2 years after receipt when stored at -20 degrees C. Store solutions at -20 degrees C in the dark.
Catalogue number: 044766
Size: 25mg
Purity: >98% (NMR)
Alternative names: (1R,2S)-1-Hydroxy-1,2,3-propanetricarboxylic acid, (2R,3S)-Isocitric acid . trisodium salt
References: Product Reference: ?Isocitrate as Calcium Ion Activity Buffer in Coagulation Assays: M. Ranby, et al.; Clin. Chem. 45, 1176 (1999) ?Syntheses with a Chiral Building Block from the Citric Acid Cycle: (2R,3S)-Isocitric Acid by Fermentation of Sunflower Oil: P. Heretsch, et al.; Angew. Chem. Int. Ed. 47, 1958 (2008) ?Cancer-associated IDH1 mutations produce 2-hydroxyglutarate: L. Dang, et al.; Nature 462, 739 (2009) ?Iron control of erythroid development by a novel aconitase-associated regulatory pathway: G.C. Bullock, et al.; Blood 116, 97 (2010) ?

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