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DTD1, Recombinant, Human, aa1-209, His-Tag (D-tyrosyl-tRNA Deacylase 1, bA379J5.3, bA555E18.1, C20orf88, DUEB, HARS2, pqn-68)

Cat no: 138644

DTD1, Recombinant, Human, aa1-209, His-Tag (D-tyrosyl-tRNA Deacylase 1, bA379J5.3, bA555E18.1, C20orf88, DUEB, HARS2, pqn-68)

DTD1 hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). It could be a defense mechanism against a harmful effect of D-tyrosine. DTD1 may be a risk factor for aspirin-intolerant asthma (AIA) by catalyzing the hydrolysis of D-tryptophan and interacting with the tyrosyl-tRNA synthetase (tyrRS) enzyme, which promotes a pro-inflammatory phenotype. This protein is localize to the DUE(DNA unwinding element )s of active replication origins. \n\nSource:\nRecombinant protein corresponding to aa1-209 from human DTD1 at N-terminal, fused to His-tag expressed in E.coli. \n\nMolecular Weight: \n~25.9kD (232aa) \n\nAA Sequence:\nMGSSHHHHHH SSGLVPRGSH MGSMKAVVQR VTRASVTVGG EQISAIGRGI CVLLGISLED TQKELEHMVR KILNLRVFED ESGKHWSKSV MDKQYEILCV SQFTLQCVLK GNKPDFHLAM PTEQAEGFYN SFLEQLRKTY RPELIKDGKF GAYMQVHIQN DGPVTIELES PAPGTATSDP KQLSKLEKQQ QRKEKTRAKG PSESSKERNT PRKEDRSASS GAEGDVSSER EP\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

138644

Size

20ug

Form

Supplied as a liquid in 20mM tris-HCl buffer, pH 8.0, 0.1M sodium chloride, 1mM DTT, 10% glycerol.

Purity

~85% (SDS-PAGE)

References

1. Pasaje CF, et al. (2011) Int J Mol Med. 28(1):129-37. 2 Chowdhury A, et al. (2010) Mol Cell Biol. 30(6):1495-507.

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