DUSP10, ID (DUSP10, MKP5, Dual specificity protein phosphatase 10, Mitogen-activated protein kinase phosphatase 5) (Biotin)

Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAPK superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAPKs, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product binds to and inactivates p38 and SAPK/JNK, but not MAPK/ERK. Its subcellular localization is unique; it is evenly distributed in both the cytoplasm and the nucleus. This gene is widely expressed in various tissues and organs, and its expression is elevated by stress stimuli. Three transcript variants encoding two different isoforms have been found for this gene.\n\nApplications:\nSuitable for use in Western Blot, ELISA\n\nRecommended Dilution:\nELISA: 1:1,000\nWestern Blot: 1:100-500\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

034851-Biotin

Size

200ul

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Hum

Conjugates

Biotin

Form

Supplied as a liquid in PBS, pH 7.2. Contains ~0.09% sodium azide. Conjugated to Biotin.

P Type

Pab

Purity

Purified by Protein A affinity chromatography.

Isotype

IgG

References

Bailey, S.D., et al. Diabetes Care (2010) In press :\nRose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :\nTalmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)\nTephly, L.A., et al. Am. J. Respir. Cell Mol. Biol. 39(1):113-123(2008)\nTeng, C.H., et al. J. Biol. Chem. 282(39):28395-28407(2007)

Additional Info

Human

Alternative Names

DUSP10, MKP5, Dual specificity protein phosphatase 10, Mitogen-activated protein kinase phosphatase 5