DUSP12, ID (DUSP12, Dual specificity protein phosphatase 12, Dual specificity tyrosine phosphatase YVH1) (Biotin)

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is the human ortholog of the Saccharomyces cerevisiae YVH1 protein tyrosine phosphatase. It is localized predominantly in the nucleus, and is novel in that it contains, and is regulated by a zinc finger domain.\n\nApplications:\nSuitable for use in Western Blot, ELISA\n\nRecommended Dilution:\nELISA: 1:1,000\nWestern Blot: 1:100-500\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

034852-Biotin

Size

200ul

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Hum, Mouse

Conjugates

Biotin

Form

Supplied as a liquid in PBS, pH 7.2. Contains ~0.09% sodium azide. Conjugated to Biotin.

P Type

Pab

Purity

Purified by Protein A affinity chromatography.

Isotype

IgG

References

Biernacki, M.A., et al. Cancer Res. 70(3):906-915(2010)\nBonham, C.A., et al. J. Biol. Chem. 284(34):22853-22864(2009)\nSharda, P.R., et al. Biochem. J. 418(2):391-401(2009)\nGao, F., et al. Zhonghua Yi Xue Za Zhi 88(32):2250-2253(2008)\nHasstedt, S.J., et al. Ann. Hum. Genet. 72 (PT 2), 163-169 (2008) :

Additional Info

Human, mouse

Alternative Names

DUSP12, Dual specificity protein phosphatase 12, Dual specificity tyrosine phosphatase YVH1