DUSP13, CT (DUSP13, BEDP, MDSP, Dual specificity protein phosphatase 13 isoform MDSP, Branching-enzyme interacting DSP, Muscle-restricted DSP) (PE)

Members of the protein-tyrosine phosphatase superfamily cooperate with protein kinases to regulate cell proliferation and differentiation. This superfamily is separated into two families based on the substrate that is dephosphorylated. One family, the dual specificity phosphatases (DSPs) acts on both phosphotyrosine and phosphoserine/threonine residues. This gene encodes different but related DSP proteins through the use of non-overlapping open reading frames, alternate splicing, and presumed different transcription promoters. Expression of the distinct proteins from this gene has been found to be tissue specific and the proteins may be involved in postnatal development of specific tissues. A protein encoded by the upstream ORF was found in skeletal muscle, whereas the encoded protein from the downstream ORF was found only in testis. In mouse, a similar pattern of expression was found. Multiple alternatively spliced transcript variants were described, but the full-length sequence of only some were determined.\n\nApplications:\nSuitable for use in Western Blot, ELISA\n\nRecommended Dilution:\nELISA: 1:1,000\nWestern Blot: 1:100-500\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Do not freeze R-Phycoerythrin conjugates. Light sensitive. Aliquots are stable for 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

034853-PE

Size

200ul

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Hum

Form

Supplied as a liquid in PBS, pH 7.2. Contains ~0.09% sodium azide. Conjugated to R-Phycoerythrin (R-PE).

P Type

Pab

Purity

Purified by Protein A affinity chromatography.

Isotype

IgG

References

Kim, S.J., et al. Proteins 66(1):239-245(2007)\nGrupe, A., et al. Am. J. Hum. Genet. 78(1):78-88(2006)\nBarrios-Rodiles, M., et al. Science 307(5715):1621-1625(2005)\nChen, H.H., et al. J. Biol. Chem. 279(40):41404-41413(2004)\nDeloukas, P., et al. Nature 429(6990):375-381(2004)

Additional Info

Human

Alternative Names

DUSP13, BEDP, MDSP, Dual specificity protein phosphatase 13 isoform MDSP, Branching-enzyme interacting DSP, Muscle-restricted DSP