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DUSP18 (Dual Specificity Protein Phosphatase 18, Low Molecular Weight Dual Specificity Phosphatase 20, LMWDSP20)

DUSP18 (Dual Specificity Protein Phosphatase 18, Low Molecular Weight Dual Specificity Phosphatase 20, LMWDSP20)

Cat no: D9840-55C

Supplier: United States Biological
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DUSP18 (E.C 3.1.3.16), a novel DSP, is a member of highly conserved protein-tyrosine phosphatase super family. Members of this family cooperate with protein kinases and play a vital role in cell cycle regulation and mitogenic signal transduction. DUSP18 is a low molecular weight protein consisting of conserved N-terminal DSP domain but lacks CH2 domain. Studies reveal that DUSP18 is a unique DSP that interacts and dephosphorylates SAPK/JNK. Reports suggest it inhibits SAPK/JNK invivo and might serve an important role in the regulation of SAPK/JNK pathway. Northern Blot analysis detected a ubiquitous expression of DUSP18. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 0.5-2ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Human or rat testis lysate Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: D9840-55C
Reactivities: Human, Bovine
Hosts: Rabbit
Applications: Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.2% gelatin, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by Protein G affinity chromatography.
References: 1. Wu et.al Biochimica et Biophysica Acta 1625 (3) 296-304 (20 February, 2003). 2. Wu et.al Front Biosci., 11; 2714-2724 (September 1, 2006).
Additional info: Recognizes human DUSP18. Species Crossreactivity: bovine, chimpanzee, orangutan, rhesus monkey. Species sequence homology: canine, rat.

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