Home  >  Products  >  DVL-1 (Segment Polarity Protein Dishevelled Homolog DVL-1, Dishevelled-1, DSH Homolog 1, DVL1)
DVL-1 (Segment Polarity Protein Dishevelled Homolog DVL-1, Dishevelled-1, DSH Homolog 1, DVL1)

DVL-1 (Segment Polarity Protein Dishevelled Homolog DVL-1, Dishevelled-1, DSH Homolog 1, DVL1)

Cat no: D9641

Supplier: United States Biological
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Segment polarity protein dishevelled homolog DVL-1 is a protein that in humans is encoded by the DVL1 gene. DVL-1 is a cytoplasmic protein that regulates the stability of B-catenin in the Wnt signalling pathway. DVL-1, the human homolog of the Drosophila dishevelled gene (dsh), encodes a cytoplasmic phosphoprotein that regulates cell proliferation, acting as a transducer molecule for developmental processes including segmentation and neuroblast specification. DVL-1 is a candidate gene for neuroblastomatous trans-formation. The Schwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2A have been mapped to the same region as DVL-1. The phenotypes of these diseases may be consistent with defects which might be expected from aberrant expression of a DVL gene during development. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 5-7ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Raji calls Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: D9641
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by Protein A affinity chromatography.
References: 1. Pizzuti, A. et al. Hum. Mol. Genet. 5:953-958 (1997). 2. Oshita, A. et al. Genes Cells 8:1005-1017 (2003).
Additional info: Recognizes human DVL-1. Species Crossreactivity: mouse, rat, rhesus monkey. Species sequence homology: bovIne, canine, equine.

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