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Dynamin 1 (DNM, Dynamin-1)

Dynamin 1 (DNM, Dynamin-1)

Cat no: D9901-22

Supplier: United States Biological
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The dynamin family of GTPases is essential for receptor-mediated endocytosis and synaptic vesicle recycling, and it has recently been shown to play a role in vesicle formation from the trans-Golgi network (1). Dynamin-1 is a GTP-, microtubule-, and phospholipid-binding protein that is expressed primarily in brain and almost exclusively expressed in the central nervous system (2). Dynamin-1 is believed to assemble around the necks of clathrin-coated pits and assist in pinching vesicles from the plasma membrane. This role would make dynamin unique among GTPases in its ability to act as a mechanochemical enzyme (1). Dynamin-1 function is apparently essential for scission of newly formed vesicles from the plasma membrane; it has been proposed that dynamin is a regulator of downstream effectors of scission, rather than being directly responsible for it (3). Applications: Suitable for use in Western Blot, Immunohistochemistry, Immunocytochemistry. Other applications not tested. Recommended Dilutions: Western Blot: 1:2000 Immunohistochemistry: 1:100-1:250 Immunocytochemistry: 1:50 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Manufactured incorporating RabMAb(R) technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.
Catalogue number: D9901-22
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Immunocytochemistry, Immunohistochemistry, Western Blot
Size: 100ul
Form: Supplied as a liquid in 50mM Tris-glycine, pH 7.4, 0.15M sodium chloride, 0.01% sodium azide, 0.05% BSA, 40% glycerol.
P type: Mab
Isotype: IgG
Purity: Supernatant
References: 1. Stomski FC, et al. Mol Cell Bio 16:3035-3046, 1996. 2. Hayashida K, et al. Proc Natl Acad Sci USA 87:9655, 1990. 3. Dirksen U, et al. J Clin Invest 100:2211-2217, 1997. 4. Weiss M, et al. Blood 82:3298, 1993
Additional info: Recogizes human Dynamin-1 at ~100kD. Species crossreactivity: mouse and rat.

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