Dynein (Cytoplasmic 1, Heavy Chain 1, DYNC1H1)

Dyneins are a group of microtubule-activated ATPases that function as molecular motors. They are divided into two subgroups of axonemal and cytoplasmic dyneins. The cytoplasmic dyneins function in intracellular motility, including retrograde axonal transport, protein sorting, organelle movement, and spindle dynamics. Molecules of conventional cytoplasmic dynein are comprised of 2 heavy chain polypeptides and a number of intermediate and light chains.This gene encodes a member of the cytoplasmic dynein heavy chain family.\n\nApplications:\nSuitable for use in ELISA. Other applications have not been tested. \n\nRecommended Dilutions: \nPeptide ELISA Titer: 1:4000\nOptimal dilutions to be determined by the researcher. \n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

D9901-51

Size

100ug

Applications

ELISA

Hosts

Goat

Reactivities

Hum

Form

Supplied as a liquid in Tris saline, pH 7.3, 0.5% BSA, 0.02% sodium azide.

P Type

Pab

Purity

Purified by peptide affinity chromatography.

Isotype

IgG

References

1. Chen XJ, Levedakou EN, Millen KJ, Wollmann RL, Soliven B, Popko B Proprioceptive sensory neuropathy in mice with a mutation in the cytoplasmic Dynein heavy chain 1 gene J Neurosci. 2007 Dec 26;27(52):14515-24

Additional Info

Recognizes DYNC1H1. Species sequence homology: human, rat.

Alternative Names

dynein, cytoplasmic-like, dynein, cytoplasmic, heavy polypeptide 1, dynein heavy chain, cytosolic, cytoplasmic dynein heavy chain, DYNC1H1 variant protein, p22, KIAA0325, HL-3, Dnchc1, DYHC, DNECL, DNCL, DNCH1, DKFZp686P2245, DHC1a, DHC1, dynein, cytoplasmic 1, heavy chain 1, DYNC1H1