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Dynorphin B

Cat no: D9902-10


Supplier: United States Biological
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Cellular Localization: Secreted Applications: Suitable for use in RID and Immunohistochemistry (Fr). Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: D9902-10
Reactivities: Rat, Guinea Pig, Non-Human Primate, Porcine, Xenopus/Amphibian
Hosts: Rabbit
Applications: Immunohistochemistry
Size: 50ul
Form: Supplied as a liquid in PBS, pH 7.2, 0.1% sodium azide, 0.1% BSA.
P type: Pab
Isotype: IgG
Purity: Serum
Alternative names: Beta-neoendorphin-dynorphin Precursor
References: Neal CR & Newman SW Prodynorphin peptide distribution in the forebrain of the Syrian hamster and rat: a comparative study with antisera against dynorphin A, dynorphin B, and the C-terminus of the prodynorphin precursor molecule. J Comp Neurol 288:353-86 (1989). Sherman TG et al. Regulation of hypothalamic magnocellular neuropeptides and their mRNAs in the Brattleboro rat: coordinate responses to further osmotic challenge. J Neurosci 8:3785-96 (1988). Khachaturian H et al. Prodynorphin peptide immunocytochemistry in rhesus monkey brain. Peptides 6 Suppl 2:155-66 (1985).
Additional info: This antibody blocks specifically with Dynorphin B 1-13. Cells are found in the paraventricular hypothalamic and the supraoptic nucleus in rat brain of colchicine treated 4% FA perfused tissue. Fibers are found in the lateral hypothalamus of both colchicine and normal rat brain of 4% FA perfused tissue. Species Crossreactivity: Crossreacts with Rat, Guinea pig, Hamster, Porcine and Rhesus monkey.Expected to crossreact with Human (100% identity with immunogen), Mouse (100% identity with immunogen), Xenopus laevis (100% identity with immunogen), Bovine (100% identity with immunogen) and Bombina orientalis (92% identity with immunogen) due to sequence homology.Antibody reactivity and working conditions may vary between species. Not yet tested in other species.

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