Dynorphin B

Cellular Localization: Secreted\n\nApplications: \nSuitable for use in RID and Immunohistochemistry (Fr). Other applications not tested.\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

D9902-10

Size

50ul

Applications

IHC

Hosts

Rabbit

Reactivities

Rat, GP, NHP, Prc, Xen/Amph

Form

Supplied as a liquid in PBS, pH 7.2, 0.1% sodium azide, 0.1% BSA.

P Type

Pab

Purity

Serum

Isotype

IgG

References

Neal CR & Newman SW Prodynorphin peptide distribution in the forebrain of the Syrian hamster and rat: a comparative study with antisera against dynorphin A, dynorphin B, and the C-terminus of the prodynorphin precursor molecule. J Comp Neurol 288:353-86 (1989). <PUBMED:2571622>Sherman TG et al. Regulation of hypothalamic magnocellular neuropeptides and their mRNAs in the Brattleboro rat: coordinate responses to further osmotic challenge. J Neurosci 8:3785-96 (1988). <PUBMED:2903913>Khachaturian H et al. Prodynorphin peptide immunocytochemistry in rhesus monkey brain. Peptides 6 Suppl 2:155-66 (1985). <PUBMED:3909123>

Additional Info

This antibody blocks specifically with Dynorphin B 1-13. Cells are found in the paraventricular hypothalamic and the supraoptic nucleus in rat brain of colchicine treated 4% FA perfused tissue. Fibers are found in the lateral hypothalamus of both colchicine and normal rat brain of 4% FA perfused tissue. Species Crossreactivity: Crossreacts with Rat, Guinea pig, Hamster, Porcine and Rhesus monkey.Expected to crossreact with Human (100% identity with immunogen), Mouse (100% identity with immunogen), Xenopus laevis (100% identity with immunogen), Bovine (100% identity with immunogen) and Bombina orientalis (92% identity with immunogen) due to sequence homology.Antibody reactivity and working conditions may vary between species. Not yet tested in other species.

Alternative Names

Beta-neoendorphin-dynorphin Precursor