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DYRK1B (Dual Specificity Tyrosine-phosphorylation-regulated Kinase 1B, Minibrain-related Kinase, Mirk Protein Kinase, MIRK)

DYRK1B (Dual Specificity Tyrosine-phosphorylation-regulated Kinase 1B, Minibrain-related Kinase, Mirk Protein Kinase, MIRK)

Cat no: D9904-05

Supplier: United States Biological
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DYRK1B is a member of the DYRK/minibrain family of dual specificity tyrosine-regulated, arginine-directed protein kinases. It is a serine/threonine protein kinase which is expressed at elevated levels in normal skeletal muscle and certain carcinoma cell lines. It contains all motifs characteristic for the DYRK family of protein kinases. In addition, the protein also comprises a bipartite nuclear localization motif. The protein functions as a transactivator of a different transcription factor, HNF1a, to which it binds through the dimerization co-factor DcoH of HNF1a. Human DYRK1B gene is mapped to chromosome 19 (19q12-13.11). Applications: Suitable for use in ELISA. Other applications not tested. Recommended Dilution: ELISA: 1:100-1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: D9904-05
Reactivities: Human
Hosts: Rabbit
Applications: ELISA
Size: 100ul
Form: Supplied as a liquid, 0.025% sodium azide, 50% glycerol.
P type: Pab
Isotype: IgG
Purity: Serum
References: 1. Susanne, L. et al. Biochemical and Biophysical Research Communications. 254:474-479 (1999). 2. Seunghwan, L. et al. J. Biol. Chem. 277:49438-49445 (2002).
Additional info: Recognizes human DYRK1B.

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