DYRK2 is a member of the dual-specificity tyrosine-phosphorylation-regulated kinases (DYRKs) which are evolutionary conserved enzymes belonging to the CMGC family of protein kinases. All DYRKs autophosphorylate a critical tyrosine residue in the activation loop and phosphorylate substrates on serine and/or threonine residues. The protein is identified as a kinase responsible for phosphorylation of p53 at Ser46 which induces p53-dependent apoptotic cell death in response to DNA damage. Recent findings also have shown that DYRK2 phosphorylate NFATc, which regulates calcium signaling, to lead NFATc inactivation by its cytoplasmic sequestration. Like other DYRKs, the DYRK2 protein contain a canonical kinase domain located between a large N-terminal region and a short C-terminal extension, and features specific to DYRK-related kinases. Human DYRK2 gene maps to chromosome 12q15.
Applications:
Suitable for use in ELISA. Other applications not tested.
Recommended Dilution:
ELISA: 1:100-1:1000
Optimal dilutions to be determined by the researcher.
Storage and Stability:
May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
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