Home  >  Products  >  Dysadherin (FXYD Domain Containing Ion Transport Regulator 5, FXYD5, DYSAD, HSPC113, IWU1, Keratinocytes Associated Transmembrane Protein 1, KCT1, OIT2, PRO6241, RIC, UNQ2561/PRO6241)
Dysadherin (FXYD Domain Containing Ion Transport Regulator 5, FXYD5, DYSAD, HSPC113, IWU1, Keratinocytes Associated Transmembrane Protein 1, KCT1, OIT2, PRO6241, RIC, UNQ2561/PRO6241)

Dysadherin (FXYD Domain Containing Ion Transport Regulator 5, FXYD5, DYSAD, HSPC113, IWU1, Keratinocytes Associated Transmembrane Protein 1, KCT1, OIT2, PRO6241, RIC, UNQ2561/PRO6241)

Cat no: D9904-50B

Supplier: United States Biological
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This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilutions: Western Blot: 1-3ug/ml Immunohistochemistry (Paraffin): 0.1-0.3ug/ml In paraffin embedded human tonsil, stains mantle zone and to a lesser extent germinal center. Optimal dilutions to be determined by the researcher. Positive Control: Jurkat lysate Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: D9904-50B
Reactivities: Human
Hosts: Goat
Applications: Immunohistochemistry, Western Blot
Size: 100ug
Form: Supplied as a liquid in Tris saline, pH 7.3, 0.5% BSA, 0.02% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Ino Y, Gotoh M, Sakamoto M, Tsukagoshi K, Hirohashi S. Dysadherin, a cancer-associated cell membrane glycoprotein, down-regulates E-cadherin and promotes metastasis. Proc Natl Acad Sci USA. 2002 Jan 8;99(1):365-70. PMID: 11756660.
Additional info: Recognizes human Dysadherin at ~30kD.

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