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Dystrophin, CT (Duchenne Muscular Dystrophy Protein, DMD, BMD, CMD3B, DXS142, DXS164, DXS206, DXS230, DXS239, DXS268, DXS269, DXS270, DXS272, Muscular Dystrophy Duchenne and Becker Types)

Dystrophin, CT (Duchenne Muscular Dystrophy Protein, DMD, BMD, CMD3B, DXS142, DXS164, DXS206, DXS230, DXS239, DXS268, DXS269, DXS270, DXS272, Muscular Dystrophy Duchenne and Becker Types)

Cat no: D9910-11B

Supplier: United States Biological
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Dystrophin is a rod-like cytoskeletal protein found adja- cent to the muscle membrane. It is one component of a complex system that links actin on the inside of muscle fibers to extracellular matrix proteins that surround the fibers. Mutations in the genes that encode for dys- trophin lead to altered expression of this protein and cause muscular dystrophy. This antibody will help detect dystrophin in normal tissue sections. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1:10-1:25 Immunohistochemistry: 1:20 for 1 hr. at RT (neat) Optimal dilutions to be determined by the researcher. Positive Control: Western Blot: Skeletal muscle, single strong band at ~400kD. Immunohistochemistry: Snap frozen normal human or rat striated muscle (staining pattern continuous rim of staining at the periphery of muscle fibers) Storage and Stability: Lyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Reconstituted product is stable for 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: D9910-11B
Reactivities: Human, Rat, Canine, Chicken/Bird, Rabbit
Hosts: Mouse
Applications: Immunohistochemistry, Western Blot
Size: 2.5ml
Form: Supplied as a lyophilized powder in PBS, 1% BSA, 15mM sodium azide. Reconstitute with 2.5ml dH2O.
P type: Mab
Isotype: IgG1
Purity: Supernatant
References: 1.Sheriffs I N, Rampling D and Smith V V. Paraffin wax embedded muscle is suitable for the diagnosis of muscular dystrophy. Journal of Clinical Pathology. 54:517-520 (2001).
Additional info: Recognizes human Dystrophin. Species Crossreactivity: Canine, chicken, hamster, rabbit and rat.

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