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EAR2 (Nuclear Receptor Subfamily 2 Group F Member 6, V-erbA-related Protein 2, EAR-2, NR2F6, ERBAL2)

EAR2 (Nuclear Receptor Subfamily 2 Group F Member 6, V-erbA-related Protein 2, EAR-2, NR2F6, ERBAL2)

Cat no: E3451-01B

Supplier: United States Biological
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NR2F6, also known as Nuclear receptor subfamily 2 group F member 6, is a nuclear protein belonging to the nuclear hormone receptor family and NR2 subfamily with a nuclear receptor DNA-binding domain. NR2F6 is a nuclear receptor involved in action regulation of the transcription of the GNRH1 gene. It binds to the TGACCT repeat motif enhancing the renin gene and thus acting as a negative modulator of renin gene transcription. NR2F6 is required early in the development of the locus ceruleus (LC), thus in some way contributing to the regulation of the forebrain clock, at least in part, through targeted release of noradrenalin into the cortical area. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 0.5-1ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Mouse Embryo Brain lysate Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: E3451-01B
Reactivities: Human, Mouse, Canine
Hosts: Rabbit
Applications: Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Miyajima, N. et al. Nucleic Acids Res. 16:11057-11073 (1988). 2. Liu, X. et al. Circ. Res. 92:1033-1040 (2003). 3. Warnecke, M. et al. Genes Dev. 19:614-625 (2005).
Additional info: Recognizes human EAR2. Species Crossreactivity: chimpanzee and canine. Species sequence homology: monkey, mouse, rat.

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