Embryonic stem cells (ESCs), derived from the inner cell mass (ICM) of blastocyst-stage embryos, are pluripotent and have a virtually unlimited capacity for self-renewal. They can differentiate into all cell types comprised of all three embryonic germ layers (ectoderm, mesoderm and endoderm). The formation of embryoid bodies (EBs) is a standard in vitro test in the differentiation of ES cells. When maintained in the EB formation medium and in the absence of MEF feeder layers, ES cells differentiate spontaneously, and form three-dimensional aggregates. This structure facilitates multicellular interactions, in which cell-cell contact occurs and gap juncitons are established. OriCell Embryoid Body (EB) Formation Medium has been optimized and qualified to support the formation of EB. The medium can be used to form EB from hanging drops in suspension culture on non-adhesive petri dishes.
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