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EBV-Induced Gene 3 (EBI3, Interleukin-27 subunit beta, IL-27 subunit beta, IL-27B, Epstein-Barr virus-induced gene 3 protein)

EBV-Induced Gene 3 (EBI3, Interleukin-27 subunit beta, IL-27 subunit beta, IL-27B, Epstein-Barr virus-induced gene 3 protein)

Cat no: E3440-50A

Supplier: United States Biological
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Epstein-Barr virus-induced gene protein 3 (EBI3), also known as Interleukin-27 beta chain (IL27B) is a widely expressed homolog to the interleukin IL-12p40 subunit protein. It forms a heterodimer with either IL-12p35 or an IL-12p35 homologue, IL27-p28 (also called IL-28), to create a new cytokine (IL-27). IL-27 plays an important function in regulating the activity of B and T lymphocytes. It drives rapid clonal expansion of naive CD4(+) T-cells and strongly synergizes with IL-12 to trigger IFN-gamma production of naive CD4(+) T-cells. The human Ebi3 encodes a secreted glycoprotein that is expressed in the spleen and tonsils, and at high levels in full-term placenta. Applications: Suitable for use in ELISA. Other applications not tested. Recommended Dilution: ELISA: 1:32000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: E3440-50A
Reactivities: Human
Hosts: Goat
Applications: ELISA
Size: 100ug
Form: Supplied as a liquid in Tris, pH 7.2, 0.5% BSA, 0.02% sodium azide.
P type: Pab
Purity: Purified by affinity chromatography.
References: 1. Collison LW, Workman CJ, Kuo TT, Boyd K, Wang Y, Vignali KM, Cross R, Sehy D, Blumberg RS, Vignali DA. The inhibitory cytokine IL-35 contributes to regulatory T-cell function. Nature. 2007 Nov 22;450(7169):566-9. PMID: 18033300
Additional info: Recognizes human EBI3.

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