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EDG-3 (EDG3, S1P3, Sphingosine 1-phosphate Receptor-3, LPB3, S1PR3) (PE)

Cat no: 145451

EDG-3 (EDG3, S1P3, Sphingosine 1-phosphate Receptor-3, LPB3, S1PR3) (PE)

Sphingosine 1-phosphate receptor-3 (S1P3); also known as EDG-3, is a 378 amino acid (aa) seven transmembrane receptor for the lysolipid phosphoric acid mediator, sphingosine 1-phosphate (S1P). Interactions between S1P3 and S1P induce a range of responses including vasoconstriction, brachycardia, vascular endothelial and smooth muscle cell proliferation and migration, heart and liver fibrosis, and coagulation-induced inflammation. Extracellular portions of human S1P3 show 74% aa sequence identity with mouse and rat S1P3.\n\nApplications: \nSuitable for use in Flow Cytometry. Other applications not tested.\n\nRecommended Dilution:\nFlow Cytometry: 10ul, 1x10e6 cells\nOptimal dilutions to be determined by the researcher.\n\nHybridoma: \nMouse myeloma cells with B cells from Balb/c mice.\n\nStorage and Stability:\nMay be stored at 4 degrees C before opening. DO NOT FREEZE! Stable at 4 degrees C as an undiluted liquid. Dilute only prior to immediate use. Stable for 12 months at 4 degrees C. Freezing R-Phycoerythrin (PE) conjugates will result in a substantial loss of activity. PE conjugates are sensitive to light.

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SPECIFICATIONS

Catalog Number

145451

Size

100Tests

Applications

FC

Hosts

Mouse

Reactivities

Hum

Form

Supplied as a liquid in PBS, 0.5% BSA, 0.1% sodium azide. Labeled with R-Phycoerythrin (PE).

P Type

Mab

Purity

Purified by Protein A or G affinity chromatography.

Isotype

IgG2a

Additional Info

Recognizes human S1P3/EDG-3.

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