Home  >  Products  >  EEF1E1 (p18, Eukaryotic Translation Elongation Factor 1 epsilon-1, Aminoacyl tRNA Synthetase Complex-interacting Multifunctional Protein 3, Elongation Factor p18, Multisynthase Complex Auxiliary Component p18, AIMP3)
EEF1E1 (p18, Eukaryotic Translation Elongation Factor 1 epsilon-1, Aminoacyl tRNA Synthetase Complex-interacting Multifunctional Protein 3, Elongation Factor p18, Multisynthase Complex Auxiliary Component p18, AIMP3)

EEF1E1 (p18, Eukaryotic Translation Elongation Factor 1 epsilon-1, Aminoacyl tRNA Synthetase Complex-interacting Multifunctional Protein 3, Elongation Factor p18, Multisynthase Complex Auxiliary Component p18, AIMP3)

Cat no: E2212-99E

Supplier: United States Biological
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The normal progression of cells through the cell cycle is under the control of the cyclin dependent protein kinases Cdk4 and Cdk6, which are subject to inhibition by the mitotic inhibitory protein p16. Isolated members of the p16 family have been designated p15 and p18, respectively. The p16 related protein, p18, interacts strongly with Cdk6 and, to a lesser extent, with Cdk4, but lacks apparent interaction with other Cdks. Recombinant p18 has been shown to inhibit cyclin D-Cdk6 kinase activity. In contrast to p21/p27, which forms ternary complexes with cyclin-Cdks, and only binary complexes of p15, p16 and p18 have been identified in association with Cdk4 and/or Cdk6. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1-2ug/ml for 2h at RT Optimal dilutions to be determined by the researcher. Positive Control: Colon carcinoma, NIH3T3 cells Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: E2212-99E
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Western Blot
Size: 50ug
Form: Supplied as a liquid in PBS, pH 7.4, 0.2% BSA, 0.05% sodium azide.
P type: Pab
Purity: Purified by immunoaffinity chromatography.
Additional info: Recognizes mouse p18. Species Crossreactivity: human and rat.

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