EGF, CT (EGF, Pro-epidermal growth factor, Epidermal growth factor, Urogastrone) (PE)

This gene encodes a member of the epidermal growth factor superfamily. The encoded protein is synthesized as a large precursor molecule that is proteolytically cleaved to generate the 53-amino acid epidermal growth factor peptide. This protein acts a potent mitogenic factor that plays an important role in the growth, proliferation and differentiation of numerous cell types. This protein acts by binding the high affinity cell surface receptor, epidermal growth factor receptor. Defects in this gene are the cause of hypomagnesemia type 4. Dysregulation of this gene has been associated with the growth and progression of certain cancers. Alternate splicing results in multiple transcript variants.\n\nApplications:\nSuitable for use in Western Blot, ELISA\n\nRecommended Dilution:\nELISA: 1:1,000\nWestern Blot: 1:100-500\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Do not freeze R-Phycoerythrin conjugates. Light sensitive. Aliquots are stable for 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

034957-PE

Size

200ul

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Hum

Form

Supplied as a liquid in PBS, pH 7.2. Contains ~0.09% sodium azide. Conjugated to R-Phycoerythrin (R-PE).

P Type

Pab

Purity

Purified by Protein A affinity chromatography.

Isotype

IgG

References

de Diesbach, M.T., et al. Exp. Cell Res. 316(19):3239-3253(2010)\nXu, Z., et al. Biochem. Biophys. Res. Commun. 401(3):376-381(2010)\nLupien, M., et al. Genes Dev. 24(19):2219-2227(2010)\nHommel, U., et al. J. Mol. Biol. 227(1):271-282(1992)\nHernandez-Sotomayor, S.M., et al. J. Membr. Biol. 128(2):81-89(1992)

Additional Info

Human

Alternative Names

EGF, Pro-epidermal growth factor, Epidermal growth factor, Urogastrone