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EGFR, CT (Epidermal Growth Factor Receptor, Proto-oncogene c-ErbB-1, Receptor Tyrosine-protein Kinase erbB-1, ERBB1)

EGFR, CT (Epidermal Growth Factor Receptor, Proto-oncogene c-ErbB-1, Receptor Tyrosine-protein Kinase erbB-1, ERBB1)

Cat no: E3375-03P

Supplier: United States Biological
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EGFR (epidermal growth factor receptor) is expressed in nearly all tissues of the zebrafish. Its counterpart, EGF (epidermal growth factor) is expressed within the ovary and testis. Within the ovaries, EGFR expression is limited to follicle cells, suggesting that it plays a role in regulation of follicle cells by oocytes expressing EGF. Zebrafish are particularly well suited to animal model studies of the cardiovascular system due to their transparent physiology in the embryo stage. A study of inhibition of zebrafish EGRF showed that it has a crucial role in cardiovascular function, as evidenced by resulting defects. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:500-1:1000 ELISA: 1:5000-1:20,000 Optimal dilutions to be determined by the researcher. Control Peptide: E3375-03Q Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: E3375-03P
Reactivities: Zebrafish/Fish
Hosts: Rabbit
Applications: ELISA, Western Blot
Size: 250ul
Form: Supplied as a liquid in 40mM MOPS, pH 7.5, 0.1% BSA, 0.05% sodium azide, 50% glycerol.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Wang, Y and Ge, W (2004) Biol. Reprod. 71(3): 749-760. 2. Goishi, K et al (2003) Mech. Dev. 120(7): 811-822.
Additional info: Recognizes zebrafish EGFR.

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