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EGFR, Phosphorylated (Tyr869) (Epidermal Growth Factor Receptor, Proto-oncogene c-ErbB-1, Receptor Tyrosine-protein Kinase erbB-1, ERBB1)

EGFR, Phosphorylated (Tyr869) (Epidermal Growth Factor Receptor, Proto-oncogene c-ErbB-1, Receptor Tyrosine-protein Kinase erbB-1, ERBB1)

Cat no: E3375-03M

Supplier: United States Biological
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The epidermal growth factor receptor (EGFR), belongs to a family of receptor tyrosine kinase in mammals, which is composed of four members: EGFR (ErB1), ErB2, ErB3, and ErB4. EGFR is a 133kD trans-membrane glycoprotein. It consists of an extracellular ligand binding domain, a single a-helical transmembrane pass, an intracellular tyrosine kinase domain, and a COOH-terminal region that contains auto-phosphorylation sites. The binding of specific polypeptide ligands, including EGF, transforming growth factor-a, ?cellulin, heparin-binding EGF, epiregulin, or amphiregulin, results in phosphorylation of multiple tyrosine residues in the COOH-terminal tail, such as tyrosine Y869, Y1016, Y1092, Y1110, Y1125, Y1172, Y1197, etc. The binding of phosphorylated EGFR tyrosines with downstream signaling proteins initiates multiple signaling cascades that culminate in cell proliferation, migration, protein secretion, differentiation and/or oncogenesis. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 0.5-2ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: E3375-03M
Reactivities: Human
Hosts: Rabbit
Applications: Western Blot
Size: 25ug
Form: Supplied as a liquid in PBS, pH 7.4, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Ullrich, A. et al. Nature 309, 418 (1984). 2. Wells, A. Int J Biochem Cell Biol 31, 637 (1999). 3. Ullrich, A. et al. Cell 61,203 (1990).
Additional info: Recognizes human EGFR when phosphorylated at Tyr869.

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