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EGFR, TK Domain (Epidermal Growth Factor Receptor, Proto-oncogene c-ErbB-1, Receptor Tyrosine-protein Kinase erbB-1, ERBB1)

EGFR, TK Domain (Epidermal Growth Factor Receptor, Proto-oncogene c-ErbB-1, Receptor Tyrosine-protein Kinase erbB-1, ERBB1)

Cat no: E3375-03N

Supplier: United States Biological
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The EGFR, epidermal growth factor receptor, belongs to a family of receptor tyrosine kinases in mammals, which is composed of four members: EGFR (Erb B1), Erb B2, ErbB3 and ErbB4. EGFR is a 1210aa residue trans-membrane glycoprotein, which can binds to Epidermal Growth Factor (EGF), Transforming Growth Factor-a (TGF-a), Heparin-binding EGF (HB-EGF), amphiregulin, beta-cellulin and epiregulin and can reveals close similarity between the entire predicted v-Erb-B mRNA oncogene product and the receptor transmembrane and cytoplasmic domains. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 0.5-2ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: E3375-03N
Reactivities: Human, Mouse, Rat, Bovine, Non-Human Primate, Rabbit
Hosts: Rabbit
Applications: Western Blot
Size: 50ug
Form: Supplied as a liquid in PBS, pH 7.4, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Ullrich, A. et al. Nature 309, 418 (1984). 2. Wells, A. Int I Biochem cell Biol. 31, 637 (1999). 3. Cuadrado, A., et al. J. Biol. Chem. 278(1): 241- 250 (2003). 4. Piiper, A., et al. J. Biol. Chem. 277(46): 43623-43630 (2002). 5. Moro, L., et al. J. Biol. Chem. 277(11): 9405-9414 (2002). 6. Janne, P.A., et al. Cancer Res. 62(18): 5242- 5247 (2002).
Additional info: Recognizes human EGFR. Species Crossreactivity: mouse, rat, rabbit, chimpanzee, monkey and bovine.

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