EGFRvIII Antibody

Cat no: 250632

Supplier: ABBIOTEC

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Description
Additional Information

Epidermal growth factor receptor (EGFR) is a receptor for EGF and for various members of the EGF family such as TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth factor, GP30 and vaccinia virus growth factor. EGFR is involved in the control of cell growth and differentation. Binding of EGF to the receptor leads to dimerization, internalization of the EGF-receptor comple, Xenopus/Amphibian,, induction of the tyrosine kinase activity, stimulation of cell DNA synthesis and cell proliferation. EGFRvIII has an 801-bp in-frame deletion resulting in a shorter e, Xenopus/Amphibian,tracellular domain (aa 6-273 are deleted) with generation of a glycine residue at the fusion point. EGFRvIII is tumor specific and is not e, Xenopus/Amphibian,pressed in normal human tissues. Defects in EGFR are associated with lung cancer.

Catalogue number:	250632
Reactivities:	Human
Applications:	Western Blot
Size:	0.1 mg
Accession:	P00533
Antigen:	KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human EGFRvIII.
Format:	Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
P type:	Rabbit Polyclonal Antibody
Isotype:	Rabbit Ig
Additional info:	Epidermal growth factor receptor; receptor tyrosine-protein kinase ErbB-1; EGFR; ERBB1; EGFRvIII; EGFR variant III