EIF2AK1 Polyclonal Antibody

Prices direct from Biomatik Corporation

Quick response times

Exclusive Biosave savings/discounts

SPECIFICATIONS

Price

323.00 USD

Catalog Number

CAC07983

Size

100 micro g

Applications

IF, IHC, WB

Hosts

Rabbit

Conjugates

Unconj

Purity

Protein G purified, >95%

Target

EIF2AK1

Clonality

Polyclonal

Storage Temp

Aliquot and store at -20 degrees C. Minimize freezing and thawing.

Research Area

For research use only. Not for diagnostic procedures.

Shipping Temp

Blue ice

Additional Info

Inhibits protein synthesis at the translation initiation level, in response to various stress conditions, including oxidative stress, heme deficiency, osmotic shock and heat shock. Exerts its function through the phosphorylation of EIF2S1 at 'Ser-48' and 'Ser-51', thus preventing its recycling. Binds hemin forming a 1:1 complex through a cysteine thiolate and histidine nitrogenous coordination. This binding occurs with moderate affinity, allowing it to sense the heme concentration within the cell. Thanks to this unique heme-sensing capacity, plays a crucial role to shut off protein synthesis during acute heme-deficient conditions. In red blood cells (RBCs), controls hemoglobin synthesis ensuring a coordinated regulation of the synthesis of its heme and globin moieties. Thus plays an essential protective role for RBC survival in anemias of iron deficiency. Similarly, in hepatocytes, involved in heme-mediated translational control of CYP2B and CYP3A and possibly other hepatic P450 cytochromes. May also contain ER stress during acute heme-deficient conditions (By similarity).

Alternative Names

Eukaryotic translation initiation factor 2-alpha kinase 1,Heme-controlled repressor,HCR,Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase,Heme-regulated inhibitor,Hemin-sensitive initiation factor 2-alpha kinase,EIF2AK1,HRI,KIAA1369,PRO1362