EIF2AK3 (5G5) Antibody

Cat no: 253074

Supplier: ABBIOTEC

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Description
Additional Information

EIF2AK3 (Eukaryotic translation initiation factor 2-alpha kinase 3; PERK) is a Ser/Thr protein kinase. It phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and to a rapid reduction of translational initiation and repression of global protein synthesis. PERK serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin D1. Defects in PERK are the cause of Wolcott-Rallison syndrome, an early-onset diabetes mellitus.

Catalogue number:	253074
Reactivities:	Human
Applications:	Western Blot
Size:	0.1 ml
Accession:	Q9NZJ5, NP_004827
Antigen:	Purified recombinant fragment of human EIF2AK3 e, Xenopus/Amphibian,pressed in E. coli.
Format:	Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
P type:	Mouse Monoclonal Antibody
Isotype:	Mouse IgG1
Clonality:	5G5
Additional info:	Eukaryotic translation initiation factor 2-alpha kinase 3; PRKR-like endoplasmic reticulum kinase; Pancreatic eIF2-alpha kinase; HsPEK; EIF2AK3; PEK; PERK