Home  >  Products  >  eIF2C1 (Eukaryotic Translation Initiation Factor 2C1, Argonaute 1, AGO1, Golgi Endoplasmic Reticulum Protein 95kD, GERP95, Q99, Putative RNA-binding Protein Q99)
eIF2C1 (Eukaryotic Translation Initiation Factor 2C1, Argonaute 1, AGO1, Golgi Endoplasmic Reticulum Protein 95kD, GERP95, Q99, Putative RNA-binding Protein Q99)

eIF2C1 (Eukaryotic Translation Initiation Factor 2C1, Argonaute 1, AGO1, Golgi Endoplasmic Reticulum Protein 95kD, GERP95, Q99, Putative RNA-binding Protein Q99)

Cat no: E2237-25B

Supplier: United States Biological
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Small non-coding RNAs are important regulators of gene expression in higher eukaryotes (1,2). Several classes of small RNAs, including short interfering RNAs (siRNAs) (3), microRNAs (miRNAs) (4) and Piwi-interacting RNAs (piRNAs) (5), have been identified. MicroRNAs are about 21 nucleotides in length and have been implicated in many cellular processes such as development, differentiation and stress response (1,2). MicroRNAs regulate gene expression by modulating mRNA translation or stability (2). MicroRNAs function together with the protein components in the complexes called micro-ribonucleoproteins (miRNPs) (2). Among the most important components in these complexes are Argonaute proteins (1,2). There are four members in the mammalian Argonaute family and only Argonaute 2 (Ago2) possesses the Slicer endonuclease activity (1,2). Argonaute proteins participate in the various steps of microRNA-mediated gene silencing such as repression of translation and mRNA turnover (1). Applications: Suitable for use in Western Blot and Immunoprecipitation. Other applications not tested. Recommended Dilutions: Western Blot: 1:1000 Immunoprecipitation: 1:50 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: E2237-25B
Reactivities: Human, Mouse, Rat, Non-Human Primate
Hosts: Rabbit
Applications: Immunoprecipitation, Western Blot
Size: 100ul
Form: Supplied as a liquid in 10mM sodium HEPES, pH 7.5, 150mM sodium chloride, 0.1mg/ml BSA, 50% glycerol.
P type: Pab
Isotype: IgG
Purity: Purified by Protein A and peptide affinity chromatography.
References: 1. Peters, L. and Meister, G. (2007) Mol Cell 26, 611-23. 2. Filipowicz, W. et al. (2008) Nat Rev Genet 9, 102-14. 3. Caplen, N.J. et al. (2001) Proc Natl Acad Sci USA 98, 9742-7. 4. Mourelatos, Z. et al. (2002) Genes Dev 16, 720-8. 5. Girard, A. et al. (2006) Nature 442, 199-202.
Additional info: Recognizes endogenous levels of total human eIF2C1 at ~97kD. Species Crossreactivity: Mouse, rat and monkey

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