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eIF3D (Eukaryotic Translation Initiation Factor 3 Subunit D, eIF3d, Eukaryotic Translation Initiation Factor 3 Subunit 7, eIF-3-zeta, eIF3 p66, EIF3S7)

eIF3D (Eukaryotic Translation Initiation Factor 3 Subunit D, eIF3d, Eukaryotic Translation Initiation Factor 3 Subunit 7, eIF-3-zeta, eIF3 p66, EIF3S7)

Cat no: E2237-98B

Supplier: United States Biological
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eIF3D is a protein belonging to the largest of the eukaryotic translation initiation factor family, eukaryotic translation initiation factor-3 (eIF3). eIF3 is a multiprotein complex composed of at least 13 different subunits. eIF3D binds to the 40S ribosomal subunit and thus helps in maintaining the 40S and 60S ribosomal subunits in a dissociated state. An important role of eIF3D is the formation of the 40S initiation complex by interacting with the ternary complex of eIF2:GTP:methionyl-tRNA, and promotes mRNA binding. eIF3D is the major RNA binding subunit of the eIF3 complex. It associates with the subunit p170 of eIF-3. Ubiquitous expression of eIF3D is seen in most of the tissues and it is phosphorylated upon DNA damage, likely by ATM or ATR. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 0.005-0.1ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Brain Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: E2237-98B
Reactivities: Human, Mouse, Rat, Zebrafish/Fish
Hosts: Rabbit
Applications: Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Asano, K. et al. J. Biol. Chem. 272:27042-27052 (1997). 2. Rush, J. et al. Nat. Biotechnol. 23:94-101 (2005).
Additional info: Recognizes human eIF3D. Species Crossreactivity: chimpanzee, macaque, mouse, orangutan, rat, rhesus monkey, zebrafish. Species sequence homology: chicken, bovine, canine, equine, opossum.

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