EliKine™ Thyroxine (T4) ELISA Kit

T4 is a useful marker for the diagnosis of hypothyroidism and hyperthyroidism. The level of T4 is decreased in hypothyroid patients and is increased in hyperthyroid patients. The major form of thyroid hormone in the blood is thyroxine (T4), which has a longer half-life than T3. In humans, the ratio of T4 to T3 released into the blood is between 14:1 and 20:1. T4 is converted to the active T3 (three to four times more potent than T4) within cells by deiodinases (5'-iodinase). These are further processed by decarboxylation and deiodination to produce iodothyronamine (T1a) and thyronamine (T0a). All three isoforms of the deiodinases are selenium-containing enzymes, thus dietary selenium is essential for T3 production. Edward Calvin Kendall was responsible for the isolation of thyroxine in 1915.

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SPECIFICATIONS

Catalog Number

KET0007

Size

48T, 96T, 96T*5

Applications

ELISA

Reactivities

Hum, Mouse, Rat, Bov, Goat, Rabbit, Sheep

Additional Info

EliKineв„ў T4 ELISA Kit has high sensitivity and excellent specificity for detection of T4. No significant cross-reactivity or interference between T4 and analogues was observed.