ELK1 (ETS Domain-containing Protein Elk-1)

Elk-1 belongs to the ternary complex (TCF) subfamily of the ETS-domain transcription factor. The protein contains the four functional domains characteristic of all members of the TCF family. The TCFs are major nuclear targets for the RAS-MAPKs of the extracellular-signal regulated kinase (ERK) subfamily, and the closely related SAPK/JNK and p38MAPK stress-activated protein kinases. In vitro, Elk-1 functions as a transcriptional activator via its association with serum response factor (SRF) in a ternary complex on the serum response element (SRE) of many immediate early genes. De-regulation of Elk-1 expression has been associated with cancers of the prostrate and breast, as well as certain T-cell malignancies. Elk-1 is a key player in the integration of mitogenic and stress-mediated signalling pathways. Human Elk-1 gene is mapped to chromosome Xp11.2.\n\nApplications:\nSuitable for use in Immunohistochemistry. Other applications not tested.\n\nRecommended Dilution:\nImmunohistochemistry (Formalin fixed paraffin embedded): 1:50-1:100\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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