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Elk1, phosphorylated (Thr417) (ETS Domain-containing Protein Elk-1)

Elk1, phosphorylated (Thr417) (ETS Domain-containing Protein Elk-1)

Cat no: E2240-10P

Supplier: United States Biological
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Elk-1 belongs to the ternary complex (TCF) subfamily of the ETS-domain transcription factor. The protein contains the four functional domains characteristic of all members of the TCF family. The TCFs are major nuclear targets for the RAS-MAPKs of the extracellular-signal regulated kinase (ERK) subfamily, and the closely related SAPK/JNK and p38MAPK stress-activated protein kinases. In vitro, Elk-1 functions as a transcriptional activator via its association with serum response factor (SRF) in a ternary complex on the serum response element (SRE) of many immediate early genes. De-regulation of Elk-1 expression has been associated with cancers of the prostrate and breast, as well as certain T-cell malignancies. Elk-1 is a key player in the integration of mitogenic and stress-mediated signalling pathways. Human Elk-1 gene is mapped to chromosome Xp11.2. Applications: Suitable for use in Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry (Formalin fixed paraffin embedded): 1:50-1:100 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: E2240-10P
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Immunohistochemistry
Size: 50ug
Form: Supplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Tanguy, A. et al. Nucleic Acids Research. 35:4649-4663 (2007). 2. Janknecht, R. et al. Oncogene. 9:1273-1278 (1997).
Additional info: Recognizes human Elk1 when phosphorylated at Thr417. Species Crossreactivity: mouse and rat.

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