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Elongin A (Elongin-A, Ela1, EloA, Elongin 110kD Subunit, RNA Polymerase II Transcription Factor SIII Subunit A1, SIII, SIII p110, Transcription Elongation Factor B (SIII) Polypeptide 3 110kD, TCEB3, TCEB3A)

Cat no: E2250

Elongin A (Elongin-A, Ela1, EloA, Elongin 110kD Subunit, RNA Polymerase II Transcription Factor SIII Subunit A1, SIII, SIII p110, Transcription Elongation Factor B (SIII) Polypeptide 3 110kD, TCEB3, TCEB3A)

Elongin A is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation.\n\nApplications:\nSuitable for use in tumor suppression. Other applications have not been tested.\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nSuggested secondary antibodies: \nI1906 IgY, Chicken Pab Rb x Ch \nI1906-10 IgY, Chicken-HRP Rb x Ch \nI1906-12 IgY, Chicken-FITC Rb x Ch \nI1906-14 IgY, Chicken-AP Rb x Ch\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage, store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

E2250

Size

1mg

Hosts

Ch/Bird

Reactivities

Hum

Form

Tris buffer, pH 7.4, 0.05% sodium azide, 25% glycerol

P Type

Pab

Purity

Purified by solvent extraction and column chromatography.

Isotype

IgY

Additional Info

Recognizes Elongin A.

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