Its function is not clear, but it has been demonstrated that the human Elongator facilitates transcription by RNA polymerase II in a chromatin- and acetyl-CoA-dependent manner. IKBKAP. IKBKAP was originally described as a scaffold protein of the IKK complex involved in NF-kB activation, but this role has since been disputed. IKBKAP is a component of the RNA polymerase II elongator complex which has histone acetyltransferase activity and is involved in transcriptional elongation. Gene defects are a cause of familial dysautonomia, also known as Riley-Day syndrome. Affected individuals show a variety of symptoms such as decreased sensitivity to pain and temperature, cardiovascular instability, pneumonia and gastrointestinal dysfunction.
Applications:
Suitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested.
Recommended Dilution:
Western Blot: 1:500-1:1000
Immunohistochemistry (Formalin fixed paraffin embedded): 20ug/ml
Optimal dilutions to be determined by the researcher.
Storage and Stability:
May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
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