Home  >  Products  >  EM574 (Motilide, Idremcinal, 8,9-Didehydro-N-demethyl-9-deoxo-6-deoxy-6,9-epoxy-N-(1-methylethyl)-erythromycin)

EM574 (Motilide, Idremcinal, 8,9-Didehydro-N-demethyl-9-deoxo-6-deoxy-6,9-epoxy-N-(1-methylethyl)-erythromycin)

Cat no: 044773


Supplier: United States Biological
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Shows strong gastrointestinal motor stimulating (GMS) activity. Motilin receptor agonist. Stimulates smooth muscle cell contraction. Stimulates cholinergic neurons in a non-vagal pathway. Enhances gastrointestinal contractile activity and accelerates gastric emptying. Shows orexigenic activity with affinity for the growth-hormone secretagogue receptor (GHS-R, ghrelin receptor). Storage and Stability: Short-term Storage: +4 degrees C Long-term Storage: -20 degrees C Stable for at least 3 years after receipt when stored at -20 degrees C.
Catalogue number: 044773
Size: 250ug
Purity: >97% (HPLC)
Alternative names: Motilide, Idremcinal, 8,9-Didehydro-N-demethyl-9-deoxo-6-deoxy-6,9-epoxy-N-(1-methylethyl)-erythromycin
References: Product Reference: ?Gastrointestinal motor-stimulating activity of macrolide antibiotics and the structure-activity relationship: S. Omura, et al.; J. Antibiot. (Tokyo) 38, 1631 (1985) ?Macrolides with gastrointestinal motor stimulating activity: S. Omura, et al.; J. Med. Chem. 30, 1941 (1987) ?EM574, an erythromycin derivative, is a potent motilin receptor agonist in human gastric antrum: M. Satoh, et al.; J. Pharmacol. Exp. Ther. 271, 574 (1994) ?Vagus-dependent and vagus-independent mechanisms of action of the erythromycin derivative EM574 and motilin in dogs: N. Inatomi, et al.; Jpn. J. Pharmacol. 71, 29 (1996) ?Bioactive metabolites of EM574 and EM523, erythromycin derivatives having strong gastrointestinal motor stimulating activity: Y. Funabashi, et al.; J. Antibiot. (Tokyo) 49, 794 (1996) ?EM574, an erythromycin derivative, is a motilin receptor agonist in the rabbit: F. Sato, et al.; Eur. J. Pharmacol. 322, 63 (1997) ?Effects of EM574 and cisapride on gastric contractile and emptying activity in normal and drug-induced gastroparesis in dogs: T. Tanaka, et al.; J. Pharmacol. Exp. Ther. 287, 712 (1998) ?Effect of EM574 on postprandial pancreaticobiliary secretion, gastric motor activity, and emptying in conscious dogs: T. Tanaka, et al.; Dig. Dis. Sci. 44, 1100 (1999) ?EM574, a motilide, has an orexigenic activity with affinity for growth-hormone secretagogue receptor: A. Asakawa, et al.; J. Gastroenterol. Hepatol. 18, 881 (2003) ?

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