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Emerin

Cat no: E2257

Emerin

Emerin is a serine rich protein ubiquitously expressed with highest concentration in skeletal and cardiac muscles. It is localized in the nuclear membrane and is coded by STA gene at Xq28 locus. Emerin deficiency is the main causal feature of Emery-Dreifuss muscular dystrophy (EDMD), which is a X-linked disorder leading to weakening of muscles and cardiomyopathy presented as heart block.\n\nEpitope: Near N-terminus\n\nApplications:\nImmunohistology (Formalin/paraffin): (Ab at 1:10 for 60 min at RT) Staining of formalin-fixed tissues REQUIRES boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 min.\n\nPositive Control: Tonsil\n\nCellular Localization: Perinuclear\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Store at -20 degrees C or colder. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

E2257

Size

250ul

Applications

ELISA, IHC

Hosts

Mouse

Reactivities

Hum

Form

Supplied as a liquid with 0.09% sodium azide.

P Type

Mab

Purity

Culture supernatant

Isotype

IgG1

References

1. Nagano A, et al. (1996) Nature Genetics, 12:254-259. 2. Bione S, et al. (1994) Nature Genetics, 8:323-327.

Additional Info

Recognizes Emerin. Species Crossreactivity: Human.

Read more on Supplier website

Applications

ELISA

Reactivities

Hum

More info

Applications

IF

Hosts

Mouse

More info

Applications

ELISA, WB

Hosts

Mouse

Reactivities

Hum

More info

Applications

ELISA, FC, WB

Hosts

Mouse

Reactivities

Hum

More info

Applications

ELISA, FC, IHC, WB

Hosts

Mouse

More info

Applications

IHC, WB

Hosts

Rabbit

Reactivities

Hum

More info

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Hum

More info
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