Emmprin (Extracellular Matrix Metalloproteinase (MMP) Inducer)

Degradation of the basement membrane by matrix metalloproteinases (MMPs) is an important step in the growth, invasion, metastasis, and angiogenesis of human tumors. MMP-2 and MMP-9 are key enzymes in the degradation of Type IV collagens, a major component of the basement membrane in cancer tissues. MMPs are secreted by stromal fibroblasts near tumor cell clusters, and may also be secreted by tumor cells themselves. EMMPRIN, or extracellular matrix metalloproteinase inducer, is a 58kD protein with two immunoglobulin domains that was originally purified from the plasma membrane of the human LX-1 lung carcinoma cell line. EMMPRIN has been localized on the outer surface of tumor cells, where it interacts with fibroblasts to stimulate the expression of MMPs. Although the mechanism of EMMPRIN

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SPECIFICATIONS

Catalog Number

E2260-03

Size

100ug

Applications

ELISA, IHC, WB

Hosts

Rabbit

Reactivities

Hum

Form

Supplied as a liquid in PBS, pH 7.4, 0.1% sodium azide.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

References

1. MacDougall JR, et al. Cancer Met Rev 14(4):351-362, 1995.2. Sun J, Hemler ME. Cancer Res 61:2276-2281, 2001.3. Ellis SM, et al. Cancer Res 49(12):3385-3391, 1989.4. Lim M, et al. FEBS Lett 441:88-92, 1998.5. Seulberger H, et al. Neurosci Lett 140(1):93-97, 1992.6. Biswas C, et al. Cancer Res 55(2):434-439, 2000.7. Kasinrerk W, et al. J Immunol 149(3):847-854, 1992.8. Bordador LC, et al. Int J Cancer 85(3):347-352, 2000.9. Schuster VL, et al. Biochim Biophys Acta 1311(1):13-19, 1996.10. Polette M, et al. J Histochem Cytochem 45(5):703-709, 1997.

Additional Info

Recognizes human Emmprin. On Western Blots, both the glycosylated (~55kD) and the non-glycosylated (30kD) forms of Emmprin are identified.